A LLS-funded research team at UCSF has discovered the “why” behind the stubborn resistance of acute lymphoblastic leukemia (ALL) cancer cells. It turns out the culprit is a pesky protein that helps leukemia cells stay alive. When bombarded with powerful cancer drugs, the protein works over-time, increasing its levels and helping the cancer cells resist therapy and survive.
The UCSF team, lead by Dr. Markus Müschen, MD, Ph.D., proved that knocking out this protein in drug-resistant leukemia cells, results in cancer remission. This translates into more powerful first-round therapies and decreased chance of resistance and relapse in patients! And someday soon, these brilliant minds will find ways to do the same thing with small molecules and formulate new oral drugs that are cheaper to mass produce.
It’s a one-two punch to leukemia, made possible by your support! Thank you for being part of Team Truly Relentless.